Characterization of radiation sensitivity of human squamous carcinoma A431 cells
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation.
Epidermal growth factor (EGF) has been shown to radiosensitize A431 and other human squamous carcinoma cells with high numbers of surface EGF receptors. In this study of the mechanistic basis of EGF-induced radiosensitization, both EGF and ionizing radiation caused G1 phase arrests in cycling A431 cells, but only radiation caused a G2-M arrest. However, EGF enhanced the magnitude of this G2-M a...
متن کاملEpidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells.
Alteration of the epidermal growth factor (EGF) signaling pathway occurs frequently in human cancer cells and may subsequently affect the cell survival towards anti-cancer agents. To elucidate the effect of long-term EGF treatment on the chemo-sensitivity of human cancer cells, human squamous carcinoma A431 cells (AP) were incubated continuously with 50 ng/ml EGF for 30 weeks and these cells we...
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Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leuk...
متن کاملCharacterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells.
A lipoxygenase inhibitor in the cytosolic fraction of human epidermoid carcinoma A431 cells was characterized and purified. The cytosolic inhibitor lost the inhibitory activity upon heating at 75 degrees C for 15 min or pretreating with 1 mg/ml trypsin at 37 degrees C for 60 min. Cytosol, after dialysis, lost the inhibitory activity but its inhibitory activity recovered when 1 mM GSH was added ...
متن کاملCytotoxic effect of methanolic extracts of vegetative and reproductive parts of Vinca rosea on A431, a human skin squamous carcinoma cell line
Introduction: Vinca rosea, an important medicinal plant, is well-known for its anticancer properties especially against breast cancer. In this study, we compared the cytotoxic effects of methanolic extracts of the vegetative (young and old leaves) and reproductive (flowers) organs of this plant on a human squamous cell carcinoma using MTT assay. Methods: The cytotoxic effects of Vinca rosea'...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1987
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1987.193